When you try to connect to the Desktop Client, you may see the following error message immediately after you click OK on the Login Information dialog box. This may be either a faulted state or reading from the pipe error.
The remote server returned an error: (500) Internal Server Error.
To see more details about the error, click Show Html Error.
Solution
If the error indicates that the Oracle Client cannot be found, do the following:
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On the application server, browse to the directory where Oracle is installed.
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Right-click the Oracle directory and then click Properties.
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Click the Security tab.
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Add the SDX_Server application pool identity user to the list of users for the directory and give it read access.
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Click Advanced.
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Select Replace permission entries on all child object with entries shown here that apply to child objects.
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Click OK.
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Click OK.